1, –, 4 Thus, preclinical disease can, by behavioral or other means, cause weight loss. Hence, for at least a decade before people are diagnosed clinically with dementia, there are, on average if not in each individual, appreciable reductions in physical activity and body mass index (BMI). During this period, preclinical disease can gradually affect behavior, reducing mental and physical activity, changing dietary and other habits, reducing caloric intake, and causing appreciable weight loss. The pathologic processes that eventually culminate in dementia may have slowly increasing preclinical cognitive effects for a decade or more before there is a definite clinical diagnosis.
Glossary BMI = body mass index CI = confidence interval CPRD = Clinical Practice Research Datalink ICD-10 = International Classification of Diseases, 10th Revision NHS = National Health Service RR = rate ratio
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